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Abstract The relationship between genotype and phenotype is often mediated by the environment. Moreover, gene-by-environment (GxE) interactions can contribute to variation in phenotypes and fitness. In the last 500 yr, house mice have invaded the Americas. Despite their short residence time, there is evidence of rapid climate adaptation, including shifts in body size and aspects of metabolism with latitude. Previous selection scans have identified candidate genes for metabolic adaptation. However, environmental variation in diet as well as GxE interactions likely impact body mass variation in wild populations. Here, we investigated the role of the environment and GxE interactions in shaping adaptive phenotypic variation. Using new locally adapted inbred strains from North and South America, we evaluated response to a high-fat diet, finding that sex, strain, diet, and the interaction between strain and diet contributed significantly to variation in body size. We also found that the transcriptional response to diet is largely strain-specific, indicating that GxE interactions affecting gene expression are pervasive. Next, we used crosses between strains from contrasting climates to characterize gene expression regulatory divergence on a standard diet and on a high-fat diet. We found that gene regulatory divergence is often condition-specific, particularly for trans-acting changes. Finally, we found evidence for lineage-specific selection on cis-regulatory variation involved in diverse processes, including lipid metabolism. Overlap with scans for selection identified candidate genes for environmental adaptation with diet-specific effects. Together, our results underscore the importance of environmental variation and GxE interactions in shaping adaptive variation in complex traits. 

Security failures in software arising from failures to practice secure programming are commonplace. Improving this situation requires that practitioners have a clear understanding of the foundational concepts in secure programming to serve as a basis for building new knowledge and responding to new challenges. We developed a Secure Programing Concept Inventory (SPCI) to measure students' understanding of foundational concepts in secure programming. The SPCI consists of thirty-five multiple choice items targeting ten concept areas of secure programming. The SPCI was developed by establishing the content domain of secure programming, developing a pool of test items, multiple rounds of testing and refining the items, and finally testing and inventory reduction to produce the final scale. Scale development began by identifying the core concepts in secure programming. A Delphi study was conducted with thirty practitioners from industry, academia, and government to establish the foundational concepts of secure programming and develop a concept map. To build a set of misconceptions in secure programming, the researchers conducted interviews with students and instructors in the field. These interviews were analyzed using content analysis. This resulted in a taxonomy of misconceptions in secure programming covering ten concept areas. An item pool of multiple-choice questions was developed. The item pool of 225 was administered to a population of 690 students across four institutions. Item discrimination and item difficulty scores were calculated, and the best performing items were mapped to the misconception categories to create subscales for each concept area resulting in a validated 35 item scale. 

SecTutor is a tutoring system that uses adaptive testing to select instructional modules that allow users to pursue secure programming knowledge at their own pace. This project aims to combat one of the most significant cybersecurity challenges we have today: individuals’ failure to practice defensive, secure, and robust programming. To alleviate this, we introduce SecTutor, an adaptive online tutoring system, to help developers understand the foundational concepts behind secure programming. SecTutor allows learners to pursue knowledge at their own pace and according to their own interests, based on assessments that identify and structure educational modules based on their current level of understanding. 

SecTutor is a tutoring system that uses adaptive testing to select instructional modules that allow users to pursue secure programming knowledge at their own pace. This project aims to combat one of the most significant cybersecurity challenges we have today: individuals’ failure to practice defensive, secure, and robust programming. To alleviate this, we introduce SecTutor, an adaptive online tutoring system, to help developers understand the foundational concepts behind secure programming. SecTutor allows learners to pursue knowledge at their own pace and according to their own interests, based on assessments that identify and structure educational modules based on their current level of understanding. 

Computing students are not receiving enough education and practice in secure programming. A key part of being able to successfully implement secure programming practices is the development of secure programming self-efficacy. This paper examines the development of a scale to measure secure programming self-efficacy among students participating in a secure programming clinic (SPC). The results show that the secure programming self-efficacy scale is a reliable and useful measure that correlates satisfactorily with related measures of programming expertise. This measure can be used in secure programming courses and other learning environments to assess students’ secure programming efficacy.